When cancer returns after a period of remission, it's considered a recurrence. A cancer recurrence happens because, in spite of the best efforts to rid you of your cancer, some cells from your cancer remained. These cells can grow and may cause symptoms.
These cells could be in the same place where your cancer first originated, or they could be in another part of your body. These cancer cells may have been dormant for a period of time. But for reasons that aren't understood, eventually they continued to multiply, resulting in the reappearance of the cancer.
In rare instances, you may be diagnosed with a new cancer that's completely unrelated to your first cancer. This is referred to as a second primary cancer.