Sleep aids available without a prescription can be effective for an occasional sleepless night. There are a few caveats, however.
Most sleep aids available without a prescription contain antihistamines. Tolerance to the sedative effects of antihistamines can develop quickly. The longer you take them, the less likely they are to make you sleepy.
In addition, some sleep aids available without a prescription can leave you feeling groggy and unwell the next day. This is the so-called hangover effect.
Medication interactions are possible as well, and much remains unknown about the safety and effectiveness of sleep aids available without a prescription.