Treatment for salivary gland tumors usually involves surgery to remove the tumor. People with salivary gland cancers may need additional treatments. These additional treatments can include radiation therapy, chemotherapy, targeted therapy or immunotherapy.
Surgery
Surgery for salivary gland tumors may include:
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Removing part of the affected salivary gland. If your tumor is small and located in an easy-to-access spot, your surgeon may remove the tumor and a small portion of healthy tissue around it.
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Removing the entire salivary gland. If you have a larger tumor, your surgeon may recommend removing the entire salivary gland. If your tumor extends into nearby structures, they also may be removed. Nearby structures may include the facial nerves, the ducts that connect the salivary glands, facial bones and skin.
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Removing lymph nodes in your neck. If your salivary gland tumor is cancerous, there may be a risk that the cancer has spread to the lymph nodes. Your surgeon may recommend removing some lymph nodes from your neck and testing them for cancer.
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Reconstructive surgery. After the tumor is removed, your surgeon may recommend reconstructive surgery to repair the area. If bone, skin or nerves are removed during your surgery, these may need to be repaired or replaced using reconstructive surgery.
During reconstructive surgery, the surgeon works to make repairs that improve your ability to chew, swallow, speak, breathe and move your face. You may need transfers of skin, tissue, bone or nerves from other parts of your body to rebuild areas in your mouth, face, throat or jaws.
Salivary gland surgery can be difficult because several important nerves are located in and around the glands. For example, a nerve in the face that controls facial movement runs through the parotid gland.
Removing tumors that involve important nerves may require working around and underneath the facial nerves. Sometimes the facial nerve gets stretched during surgery. This can cause loss of movement in the face muscles. Muscle movement often gets better over time. Rarely, the facial nerve must be cut in order to get all of the tumor. Surgeons can repair the facial nerve using nerves from other areas of the body or with other techniques.
Radiation therapy
If you're diagnosed with salivary gland cancer, your healthcare team may recommend radiation therapy. Radiation therapy treats cancer with powerful energy beams. The energy can come from X-rays, protons or other sources. For salivary gland cancer, radiation therapy is most often done with a procedure called external beam radiation. During this treatment, you lie on a table while a machine moves around you. The machine directs radiation to precise points on your body.
Radiation therapy can be used after surgery to kill any cancer cells that might remain. If surgery isn't possible because a tumor is very large or is located in a place that makes removal too risky, your healthcare professional may recommend radiation alone or in combination with chemotherapy.
Chemotherapy
Chemotherapy treats cancer with strong medicines. Chemotherapy isn't currently used as a standard treatment for salivary gland cancer, but researchers are studying its use.
Chemotherapy may be an option for people with advanced salivary gland cancer. It's sometimes combined with radiation therapy.
Targeted therapy
Targeted therapy for cancer is a treatment that uses medicines that attack specific chemicals in the cancer cells. By blocking these chemicals, targeted treatments can cause cancer cells to die.
For salivary gland cancer, targeted therapy may be used when the cancer can't be removed with surgery. It also may be used for advanced cancers that spread to other parts of the body or cancer that comes back after treatment.
Some targeted therapies only work in people whose cancer cells have certain DNA changes. Your cancer cells may be tested in a lab to see if these medicines might help you.
Immunotherapy
Immunotherapy for cancer is a treatment with medicine that helps the body's immune system kill cancer cells. The immune system fights off diseases by attacking germs and other cells that shouldn't be in the body. Cancer cells survive by hiding from the immune system. Immunotherapy helps the immune system cells find and kill the cancer cells.
For salivary gland cancer, immunotherapy may be used on cancer that can't be removed with surgery. It also may be used for advanced cancers that have spread to other parts of the body or cancer that has come back after treatment.
Palliative care
Palliative care is a special type of healthcare that helps you feel better when you have a serious illness. If you have cancer, palliative care can help relieve pain and other symptoms. A healthcare team that may include doctors, nurses and other specially trained health professionals provides palliative care. The care team's goal is to improve quality of life for you and your family.
Palliative care specialists work with you, your family and your care team. They provide an extra layer of support while you have cancer treatment. You can have palliative care at the same time you're getting strong cancer treatments, such as surgery, chemotherapy or radiation therapy.
The use of palliative care with other proper treatments can help people with cancer feel better and live longer.