To understand the causes of precocious puberty in some children, it's helpful to know what happens at puberty. The brain starts the process by making a hormone called gonadotropin-releasing hormone (GnRH).
When this hormone reaches the small, bean-shaped gland at the base of the brain, called the pituitary gland, it leads to more estrogen in the ovaries and more testosterone in the testicles. Estrogen makes female sex traits. Testosterone makes male sex traits.
There are two types of precocious puberty: central precocious puberty and peripheral precocious puberty.
Central precocious puberty
The cause of this type of precocious puberty often isn't known.
With central precocious puberty, puberty starts too soon but develops as usual. For most children with this condition, there's no medical problem or other known reason for the early puberty.
In rare cases, the following can cause central precocious puberty:
- A tumor in the brain or spinal cord.
- A change in the brain that's present at birth. This could be fluid buildup, known as hydrocephalus, or a tumor that isn't cancer, known as a hamartoma.
- Radiation to the brain or spinal cord.
- Injury to the brain or spinal cord.
- A rare genetic disease that affects bones and skin color and causes hormonal problems. This condition is called McCune-Albright syndrome.
- A group of genetic issues, called congenital adrenal hyperplasia, that involve the adrenal gland making atypical hormones.
- A condition called hypothyroidism in which the thyroid gland doesn't make enough hormones.
Peripheral precocious puberty
Estrogen or testosterone being made too soon causes this type of precocious puberty.
With this type of precocious puberty, the hormone in the brain (
GnRH) that typically causes puberty to start isn't involved. Instead, the cause is the release of estrogen or testosterone into the body. A problem with the ovaries, testicles, adrenal glands or pituitary gland causes the hormone release.
The following can lead to peripheral precocious puberty:
- A tumor in the adrenal glands or in the pituitary gland that releases estrogen or testosterone.
- A rare genetic disease that affects bones and skin color and causes hormonal problems. This condition is called McCune-Albright syndrome.
- Being exposed to creams or ointments that contain estrogen or testosterone.
In girls, peripheral precocious puberty also might be linked to:
- Ovarian cysts.
- Ovarian tumors.
In boys, peripheral precocious puberty also might be caused by:
- A tumor in the cells that make sperm or in the cells that make testosterone.
- A rare genetic condition called gonadotropin-independent familial sexual precocity. This can cause boys, usually between ages 1 and 4, to make testosterone too early.