The pancreas has two major roles. It produces insulin, which helps the body manage and use sugars.
The pancreas also produces dietary juices, called enzymes, that help with digestion. The pancreas makes and stores "turned off" versions of these enzymes. After the pancreas sends the enzymes into the small intestine, they are "turned on" and break down proteins in the small intestine.
If the enzymes are turned on too soon, they can start acting like digestive juices inside the pancreas. This action can irritate, damage or destroy cells. This, in turn, leads to immune system responses that cause swelling and other actions that affect how the pancreas works.
Several conditions can lead to acute pancreatitis, including:
- Blockage in the bile duct caused by gallstones.
- Heavy alcohol use or cigarette smoking.
- Certain medicines.
- High triglyceride levels in the blood.
- High calcium levels in the blood.
- Pancreatic cancer.
- Injuries from endoscopy, trauma or surgery.
Conditions that can lead to chronic pancreatitis include:
- Heavy alcohol use or cigarette smoking.
- Damage from repeated acute pancreatitis.
- Inherited conditions of the pancreas.
- High triglyceride levels in the blood.
- Autoimmune condition of the pancreas.
Sometimes, a cause of pancreatitis is never found. This is known as idiopathic pancreatitis.