Ductal carcinoma in situ (DCIS) is usually treated with surgery to remove the cancer. Sometimes other treatments are used after surgery to lower the risk that the cancer will come back. These treatments may include radiation therapy after lumpectomy surgery and estrogen blocker therapy if the DCIS is hormone receptor positive.
DCIS treatment has a high likelihood of success, and this cancer often can be cured. After treatment, the chance that DCIS will come back or become invasive is usually low.
Healthcare professionals can't always predict which cancers are more likely to come back after treatment. For this reason, they may recommend additional treatment after surgery to lower that risk. This is called adjuvant therapy.
Deciding whether to have adjuvant therapy often involves talking with your healthcare team about the possible benefits and risks. Your decision may depend on your specific situation and your preferences.
In most people, treatment options for DCIS include:
- Breast-conserving surgery, called a lumpectomy, and radiation therapy.
- Breast-removing surgery, called a mastectomy.
In some people, treatment options may include:
- Lumpectomy only.
- Lumpectomy and estrogen blocker therapy.
Surgery
If you're diagnosed with DCIS, one of the first decisions you'll have to make is whether to treat the condition with lumpectomy or mastectomy.
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Lumpectomy. A lumpectomy is surgery to remove the breast cancer and some of the healthy tissue around it. It allows you to maintain most of your breast. Other names for this surgery are breast-conserving surgery and wide local excision. Most people have radiation therapy after lumpectomy.
Research suggests that there is a slightly higher risk of the cancer coming back after lumpectomy compared with mastectomy. However, survival rates between the two treatment approaches are very similar.
If you have other serious health conditions, you might consider other options, such as lumpectomy plus hormone therapy, lumpectomy alone or no treatment.
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Mastectomy. A mastectomy is surgery to remove all breast tissue from a breast. Total mastectomy also is called simple mastectomy. It removes all of the breast, including the lobules, ducts, fatty tissue and some skin, as well as the nipple and areola. Other procedures include skin-sparing mastectomy, which leaves the skin, and nipple-sparing mastectomy, which leaves the areola, nipple and skin. Breast reconstruction to restore the appearance of the breast can be done at the same time or in a later procedure, if you desire.
Lumpectomy is a good option for most people with DCIS. But mastectomy may be recommended if:
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You have a large area of DCIS. If the area is large relative to the size of your breast, a lumpectomy may not produce acceptable cosmetic results.
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There's more than one area of DCIS. When multiple areas are involved, it is called multifocal or multicentric disease. It's difficult to remove multiple areas of DCIS with a lumpectomy. This is especially true if the areas are found in different parts of the breast.
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Biopsy results show cancer cells at or near the edge of the tissue sample. There may be more DCIS than originally thought. This means that a lumpectomy might not be enough to remove all affected areas. A mastectomy could be needed to remove all of the breast tissue.
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You're not a candidate for radiation therapy. Radiation is usually given after a lumpectomy. Radiation might not be an option if you're in the first trimester of pregnancy or if you've received radiation to your chest or breast in the past. It also might not be recommended if you have a condition that makes you more sensitive to radiation side effects, such as systemic lupus erythematosus.
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You prefer to have a mastectomy. For instance, you might not want a lumpectomy if you don't want to have radiation therapy.
Because DCIS is noninvasive, surgery typically doesn't involve the removal of lymph nodes from under your arm. The chance of finding cancer in the lymph nodes is extremely small.
If the cancer cells may have spread outside the breast duct or if you are having a mastectomy, then some lymph nodes may be removed as part of the surgery.
Radiation therapy
Radiation therapy treats cancer with powerful energy beams. The energy can come from X-rays, protons or other sources.
Radiation therapy for breast cancer often uses external beam radiation. During this type of radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to precise points on your body.
For DCIS, radiation therapy is often used after lumpectomy to reduce the chance that the cancer will come back. But it might not be necessary if you have only a small area of DCIS that is considered slow growing and was completely removed during surgery.
Radiation can be applied to the entire breast, called whole-breast radiation, or to part of the breast, called partial-breast radiation. Your healthcare team may talk about these options with you after surgery. The approach your team recommends may depend on your age and the size, grade and hormone receptor status of your cancer.
Estrogen blocker therapy
Estrogen blocker therapy treats breast cancer that is sensitive to hormones. This type of cancer has cells with proteins called receptors. The receptors attach to the hormones estrogen and progesterone. The cancer grows in response to these hormones. Healthcare professionals call these cancers hormone receptor positive. DCIS is usually sensitive to hormones.
For DCIS, estrogen blocker therapy is typically used after surgery or radiation. It lowers the risk that the cancer will come back. It also reduces the risk of developing another breast cancer.
Estrogen blocker therapy treatments can include:
- Medicines that block or destroy hormone receptors. These medicines are called selective estrogen receptor modulators. This category includes the medicine tamoxifen. It may be used before or after menopause.
- Medicines that lower hormone production. These medicines are called aromatase inhibitors. They may be used only after menopause.
Discuss the benefits and risks of estrogen blocker therapy with your healthcare team.