Benign peripheral nerve tumors are tumors that form on peripheral nerves. The peripheral nerves link the brain and spinal cord to other parts of the body. These nerves control muscles that allow you to walk, blink, swallow, pick things up and do other activities. Benign tumors are not cancerous.
Several different types of tumors may form on the peripheral nerves. While some are caused by genetics, the cause of these tumors is usually not known.
Although most of these types of tumors are not cancerous, they can cause nerve damage and loss of muscle control. It's important to see your healthcare professional if you have a lump or if you have pain, tingling, numbness or muscle weakness.
Types
Peripheral nerve tumors affect nerves by growing within them or by pressing against them. Peripheral nerve tumors that grow within nerves are called intraneural tumors. The tumors that press against nerves are called extraneural tumors. Most peripheral tumors are not cancer. These are known as benign tumors. Different types of benign peripheral nerve tumors include:
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Schwannoma. A schwannoma is the most common benign peripheral nerve tumor in adults. These nerve sheath tumors are called schwannomas because they are made up of Schwann cells. Schwann cells surround the nerves.
These tumors usually grow slowly. If you develop a schwannoma in an arm or leg, you might notice a mass. But you might have a schwannoma for years before noticing it.
A schwannoma typically comes from a single bundle of nerve fibers, called a fascicle, within the main nerve. Some schwannomas grow and form irregular shapes within the spine or pelvis, such as dumbbell tumors. When a schwannoma grows, more fascicles are at risk when trying to remove the tumor safely.
Schwannomas most commonly occur alone. Occasionally some people have several of them in the arms, legs or body. This is a condition called schwannomatosis.
A rare schwannoma near the brainstem, known as an acoustic neuroma, can cause trouble with balance or hearing. This type of tumor also is known as a vestibular schwannoma. It sometimes occurs in people with a condition called NF2-related schwannomatosis. If acoustic neuromas aren't treated and they continue to grow, they can affect nearby nerves and press on the brainstem.
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Neurofibroma. This common type of benign nerve tumor tends to form in the center of a nerve. A neurofibroma might arise from several nerve bundles and tends to cause mild symptoms. A neurofibroma most commonly develops in people who have a genetic condition that causes tumors to grow on nerves. This condition is known as neurofibromatosis type 1 (NF1).
Symptoms of NF1 include skin color changes and benign tumors on the skin. Some people who have NF1 develop other conditions. These conditions include bone changes, such as a curved spine, and an eye nerve tumor called an optic glioma. People with NF1 are at risk of developing a malignant peripheral nerve sheath tumor.
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Perineurioma. This rare benign peripheral nerve tumor arises from perineurial cells, a type of cell that surrounds the peripheral nerve sheath. A perineurioma can form within a nerve, called an intraneural perineurioma. It also may form in soft tissue next to a nerve, called an extraneural perineurioma. An intraneural perineurioma happens most often in children and young adults. It typically causes gradually progressive weakness in an arm or leg.
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Lipoma. Slow-growing fat cells cause this benign, soft lump that usually appears under the skin on the neck, shoulders, back or arms. A lipoma near a nerve can squeeze it. Usually, though, a lipoma causes no pain or other problems. Your healthcare professional might want to monitor a lipoma through regular checkups.
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Ganglion
cyst. Some ganglion cysts come from an injury, but most have no known cause. They commonly form near joints, such as the wrist, and can cause pain and interfere with everyday activities. Some go away without treatment, but ganglion cysts that press on or are in nerves need to be treated.