Multisystem inflammatory syndrome in children (MIS-C) is a serious condition linked to infection with the virus that causes COVID-19.
With MIS-C, children have fever, blood markers of inflammation and serious disease throughout the body. Organs such as the brain, eyes, heart, lungs, kidneys, digestive system and skin may become inflamed. MIS-C symptoms are treated in the hospital as the illness runs its course.
MIS-C is rare. In 2023, the U.S. Centers for Disease Control and Prevention received 117 reports of MIS-C. Most of these children had no medical issues before getting MIS-C.
Symptoms usually show up in about 2 to 6 weeks after infection with the virus that causes COVID-19.
Symptoms of MIS-C include a fever that doesn't go away, along with other symptoms:
- Vomiting.
- Diarrhea.
- Belly pain.
- Skin rash.
- Bloodshot eyes.
- Dizziness or lightheadedness.
Emergency warning signs of MIS-C include:
- Trouble staying awake or waking up.
- Difficulty breathing.
- New confusion.
- Gray or blue skin, lips or nail beds.
- Terrible belly pain.
If your child shows any emergency warning signs or is severely sick with other symptoms, take your child to the nearest emergency department or call 911 or your local emergency number. If your child isn't seriously ill but shows other symptoms of MIS-C, contact your child's healthcare professional right away for advice.
Most children get better quickly and don't have any medical issues caused by MIS-C.
Staying up to date with COVID-19 vaccination offers protection against MIS-C. And most children who have had MIS-C can get a COVID-19 vaccine on schedule.